ARMCX1


Description

The ARMCX1 (armadillo repeat containing X-linked 1) is a protein-coding gene located on chromosome X.

ARMCX1, encoded by the ARMCX1 gene, is a member of the ALEX family of proteins and may play a role in tumor suppression. It contains a potential N-terminal transmembrane domain and two Armadillo repeats, similar to other proteins involved in development, tissue maintenance, and tumorigenesis. ARMCX1 is located on the X chromosome near other family members, ALEX2 and ALEX3.

ARMCX1 regulates mitochondrial transport during axon regeneration, increasing the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. This enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons, ultimately promoting neuronal survival and axon regeneration after nerve injury. ARMCX1 may link mitochondria to the Trak1-kinesin motor complex through its interaction with MIRO1.

ARMCX1 is also known as ALEX1, GASP7.

Associated Diseases



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