ARL2-SNX15
Description
The ARL2-SNX15 (ARL2-SNX15 readthrough (NMD candidate)) is a ncRNA gene located on chromosome 11.
The ARL2-SNX15 complex is a protein complex that regulates endosomal trafficking and membrane dynamics. It is composed of the ADP-ribosylation factor-like protein 2 (ARL2) and the sorting nexin 15 (SNX15), which together control the sorting and transport of cargo within the cell.
The ARL2-SNX15 complex, composed of the ADP-ribosylation factor-like protein 2 (ARL2) and the sorting nexin 15 (SNX15), plays a crucial role in regulating endosomal trafficking and membrane dynamics. SNX15, an adaptor protein, specifically binds to phosphatidylinositol 3-phosphate (PI3P), a lipid enriched in early endosomes. Through this interaction, SNX15 recruits cargo to endosomes. ARL2, a small GTPase, binds to and activates SNX15, thereby enhancing its ability to sort and transport cargo. This complex is involved in various cellular processes, including endocytosis, recycling, and retrograde transport from endosomes to the trans-Golgi network. In addition, it has been implicated in regulating the trafficking of certain receptors, such as the epidermal growth factor receptor (EGFR), and in modulating cellular responses to growth factors.
ARL2-SNX15 is also known as -.
