ARIH2
Description
The ARIH2 (ariadne RBR E3 ubiquitin protein ligase 2) is a protein-coding gene located on chromosome 3.
ARIH2 is a protein involved in various cellular processes. It regulates the proliferation, DNA damage response, and chemosensitivity of gastric cancer cells. ARIH2 ubiquitinates NLRP3, a protein involved in inflammation, and negatively regulates the activation of the NLRP3 inflammasome. In the context of leukemia, ARIH2 influences the development of Mll-Ell-induced acute myeloid leukemia.
ARIH2, also known as Triad1, acts as an E3 ubiquitin ligase, attaching ubiquitin molecules to target proteins. It works in conjunction with the ubiquitin-conjugating enzyme E2 UBE2L3, catalyzing ubiquitination of target proteins. ARIH2 acts as an atypical E3 ubiquitin ligase by collaborating with the cullin-5-RING ubiquitin ligase complex (ECS complex). It binds to this complex and initiates ubiquitination of ECS substrates, specifically mediating the addition of the first ubiquitin. The initial ubiquitin is then elongated. ARIH2's activity is activated by binding to the neddylated form of the ECS complex. It mediates different types of polyubiquitination, including Lys-6, Lys-48, and Lys-63 linked chains, and is implicated in the process of myelopoiesis.
ARIH2 is also known as ARI2, TRIAD1.
