ARID5B
Description
The ARID5B (AT-rich interaction domain 5B) is a protein-coding gene located on chromosome 10.
ARID5B is a protein encoded by the ARID5B gene in humans. It is also known as Modulator recognition factor 23. The gene is located on the long arm of chromosome 10 (10q21.2) and spans 195,261 base pairs. It encodes a protein of predicted length 1188 amino acids and molecular weight 132.375 kilodaltons. Some of the single nucleotide polymorphisms (SNPs) located in this gene have been associated with susceptibility and treatment outcomes of childhood acute lymphoblastic leukaemia in diverse populations.
ARID5B acts as a transcription coactivator, binding to the 5'-AATA[CT]-3' core sequence and playing a crucial role in adipogenesis and liver development. It forms a complex with phosphorylated PHF2, leading to demethylation at Lys-336, targeting the PHF2-ARID5B complex to specific promoters. Here, PHF2 demethylates dimethylated 'Lys-9' of histone H3 (H3K9me2), resulting in the activation of target genes. This complex functions as a coactivator of HNF4A in the liver. ARID5B is essential for adipogenesis, regulating triglyceride metabolism in adipocytes by controlling the expression of adipogenic genes. Overexpression of ARID5B induces smooth muscle marker genes, suggesting its potential role in regulating smooth muscle cell differentiation and proliferation. Notably, ARID5B also represses the cytomegalovirus enhancer.
ARID5B is also known as DESRT, MRF-2, MRF2.
