ARID5A

Description

The ARID5A (AT-rich interaction domain 5A) is a protein-coding gene located on chromosome 2.

ARID5A, also known as Modulator Recognition Factor 1, binds to AT-rich regions upstream of the human cytomegalovirus major intermediate early gene enhancer. It may act as a repressor, downregulating enhancer-dependent gene expression. ARID5A can positively regulate chondrocyte-specific transcription, such as COL2A1, in collaboration with SOX9. It also positively regulates histone H3 acetylation at chondrocyte-specific genes, potentially stimulating early-stage chondrocyte differentiation and inhibiting later stage differentiation. Additionally, ARID5A can repress ESR1-mediated transcriptional activation and may function as a corepressor for selective nuclear hormone receptors. As an RNA-binding protein, ARID5A plays a role in regulating inflammatory responses by stabilizing specific inflammation-related mRNAs, such as IL6, STAT3, and TBX21. It binds to stem loop structures within the 3'UTRs of these mRNAs, preventing the degradation activity of ZC3H12A, particularly in the case of STAT3. This stabilization contributes to elevated IL6 levels, which may be implicated in autoimmune processes. The IL6-dependent stabilization of STAT3 mRNA promotes the differentiation of naive CD4+ T-cells into T-helper Th17 cells. ARID5A can also inhibit RORC-induced Th17 cell differentiation in CD4+ T-cells independently of IL6 signaling. Stabilizing TBX21 mRNA leads to increased interferon-gamma secretion in Th1 cells, potentially contributing to the development of septic shock. Furthermore, ARID5A stabilizes TNFRSF4/OX40 mRNA by binding to a conserved stem loop structure in its 3'UTR, thereby competing with the mRNA-destabilizing activities of RC3H1 and endoribonuclease ZC3H12A.

ARID5A is also known as MRF-1, MRF1, RP11-363D14.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing