ARID3A
Description
The ARID3A (AT-rich interaction domain 3A) is a protein-coding gene located on chromosome 19.
ARID3A (AT-rich interactive domain-containing protein 3A) is a protein encoded by the ARID3A gene in humans. It belongs to the ARID (AT-rich interaction domain) family of DNA binding proteins and is homologous to the Drosophila dead ringer gene, which is essential for normal embryonic development. Other ARID family members are involved in various cellular processes, including embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and potentially chromatin structure modification. ARID3A has been shown to interact with BTK and E2F1.
ARID3A is a transcription factor that may play a role in regulating cell cycle progression through the RB1/E2F1 pathway and in B-cell differentiation.
ARID3A is also known as BRIGHT, DRIL1, DRIL3, E2FBP1.
Associated Diseases
- ovarian cancer
- endometrial cancer
- esophageal cancer
- systemic lupus erythematosus
- hemoglobin D disease
- isolated agammaglobulinemia
- common variable immunodeficiency
