ARID2
Description
The ARID2 (AT-rich interaction domain 2) is a protein-coding gene located on chromosome 12.
ARID2 (AT-rich interactive domain-containing protein 2) is a human protein encoded by the ARID2 gene. It functions as a subunit of the PBAF chromatin-remodeling complex, which facilitates ligand-dependent transcriptional activation by nuclear receptors. The protein contains two conserved C-terminal C2H2 zinc fingers motifs, a proline and glutamine-rich region, an RFX (regulatory factor X)-type winged-helix DNA-binding domain, and a conserved N-terminal AT-rich DNA interaction domain. ARID2 has been identified as a significant tumor suppressor in many cancer types, with mutations being prevalent in hepatocellular carcinoma and melanoma. While mutations are present in a smaller proportion of other tumors, they are enriched in hepatitis C virus-associated hepatocellular carcinoma in the US and Europe compared to the overall mutation frequency.
ARID2 plays a crucial role in regulating gene expression by influencing chromatin remodeling, which involves altering the structure of DNA and nucleosomes. This protein is essential for maintaining the stability of the SWI/SNF-B (PBAF) chromatin remodeling complex. It may also contribute to directing this complex to specific genes and potentially regulates the activation of genes involved in heart development.
ARID2 is also known as BAF200, CSS6, SMARCF3, ZIPZAP, p200.
