ARAP3
Description
The ARAP3 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3) is a protein-coding gene located on chromosome 5.
ARAP3 is a protein that acts as a GTPase-activating protein (GAP). It helps control the activity of small GTPases like ARF6, RAC1, RHOA, and CDC42, which are crucial for regulating the cytoskeleton, the network of fibers that gives cells their structure and allows them to move. ARAP3 is activated by binding to the lipid phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), which suggests it plays a role in cellular signaling pathways. It can also be activated, although less efficiently, by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2). By regulating these small GTPases, ARAP3 helps to control the shape and movement of cells, and plays a role in the uptake of the anthrax toxin.
ARAP3 is also known as CENTD3, DRAG1.
