APLNR
Description
The APN/APLNR system plays a crucial role in regulating energy homeostasis, appetite control, and various other physiological processes. APLN (Apelin) is a peptide hormone primarily synthesized in the heart, with actions mediated by its receptor, APLNR (Apelin Receptor). The binding of apelin to APLNR triggers downstream signaling pathways, impacting crucial metabolic functions. Notably, the APLN/APLNR axis is implicated in the control of food intake, energy expenditure, and blood pressure regulation, demonstrating its significance in overall metabolic health.
Associated Diseases
Did you know?
Apelin, the ligand for APLNR, is derived from a precursor protein called preproapelin. It‘s remarkable that apelin exists in multiple isoforms, each with varying biological activities.
