APLN
Description
The APLN gene encodes for the apelin protein, a hormone that plays a crucial role in regulating energy metabolism, cardiovascular function, and appetite. Apelin binds to the APJ receptor, a G protein-coupled receptor, triggering various downstream signaling pathways. Its functions include promoting fat utilization, regulating insulin sensitivity, and influencing food intake. Dysregulation of the APLN gene and its signaling pathway is associated with several metabolic disorders.
Associated Diseases
Did you know?
Apelin was originally discovered in 1998 as a ligand for the APJ receptor, which was previously known as an orphan receptor.
