AP2B1

Description

The AP2B1 (adaptor related protein complex 2 subunit beta 1) is a protein-coding gene located on chromosome 17.

AP-2 complex subunit beta is a protein that in humans is encoded by the AP2B1 gene.

== Function == The protein encoded by this gene is one of two large chain components of the AP2 adaptor complex, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene.

== Interactions == AP2B1 has been shown to interact with:

== References ==

== Further reading ==

== External links == Human AP2B1 genome location and AP2B1 gene details page in the UCSC Genome Browser.

AP-2 complex subunit beta (AP2B1) is a key component of the adaptor protein complex 2 (AP-2), which plays a crucial role in protein transport within cells. AP-2 complexes are essential for the formation of clathrin-coated vesicles (CCVs), which are responsible for the internalization of cargo molecules through a process known as endocytosis. AP-2 interacts directly with both the clathrin lattice and membrane components, mediating the selection and packaging of specific cargo molecules into CCVs. AP-2 also acts as a cargo receptor, recognizing specific endocytosis signal motifs within the cytosolic tails of transmembrane proteins. In addition to its role in clathrin-dependent endocytosis, AP-2 is involved in the recycling of synaptic vesicle membranes, and it may also contribute to post-endocytic trafficking through a non-clathrin pathway. The AP-2 beta subunit (AP2B1) acts as a scaffolding platform for endocytic accessory proteins, facilitating the assembly of the clathrin coat. AP2B1 binds to clathrin heavy chain, promoting the formation of the clathrin lattice. This interaction is dynamic, with clathrin displacing certain accessory proteins from AP2B1, enabling further coat assembly.

AP2B1 is also known as ADTB2, AP105B, AP2-BETA, CLAPB1.

Associated Diseases

WES Whole Exome Sequencing