AOC2
Description
The AOC2 (amine oxidase copper containing 2) is a protein-coding gene located on chromosome 17.
AOC2 (Amine oxidase, copper containing 2) is a protein encoded by the AOC2 gene in humans. It's a copper-containing enzyme that plays a role in converting amines to aldehydes and ammonia. AOC2 shares significant similarity with amine oxidases found across various species. It contains specific motifs, including the active site and copper-binding histidine residues. AOC2 might regulate signal transmission in the retina by breaking down biogenic amines like dopamine, histamine, and putrescine. This gene is a potential candidate for hereditary eye diseases. Multiple AOC2 transcript variants arise from alternative splicing.
AOC2 catalyzes the oxidative deamination of primary amines, converting them into their corresponding aldehydes. This process also generates hydrogen peroxide and ammonia. AOC2 demonstrates a preference for specific amines, particularly 2-phenylethylamine, tryptamine, and tyramine. While it can also act on methylamine and benzylamine, its efficiency is significantly lower for these substrates.
AOC2 is also known as DAO2, RAO, SSAO.
