ANKRD6

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Description

The ANKRD6 (ankyrin repeat domain 6) is a protein-coding gene located on chromosome 6.

ANKRD6, also known as Diversin, plays a crucial role in regulating the Wnt signaling pathway by promoting the degradation of beta-catenin. It facilitates the assembly of a complex containing AXN1 or AXN2, GSK3-beta, and CKI-epsilon, which then efficiently phosphorylates beta-catenin. This phosphorylation event ultimately inhibits the beta-catenin/Tcf signaling pathway.

ANKRD6 is also known as -.

Associated Diseases

• cancer
• hearing loss, autosomal dominant 80
• autosomal recessive nonsyndromic hearing loss 4