AMOTL2
Description
The AMOTL2 gene (angiomotin-like 2) encodes a protein that plays a crucial role in regulating cell adhesion and migration, processes essential for proper tissue development. This protein interacts with various cellular components, including the cytoskeleton and cell-cell junctions, to control cell shape, movement, and organization. AMOTL2 is implicated in a diverse range of biological processes, from vascular development to wound healing, making it a significant player in maintaining tissue integrity and function.
Associated Diseases
- Developmental defects, such as heart defects and craniofacial abnormalities
- Cancer progression, including tumor growth and metastasis
- Neurological disorders, including epilepsy and intellectual disability
- Genetic syndromes, such as Joubert syndrome and Meckel-Gruber syndrome
Did you know?
AMOTL2 is found to be highly expressed in the developing brain, suggesting its potential role in neuronal development and function.
