ALDH9A1
Description
The ALDH9A1 (aldehyde dehydrogenase 9 family member A1) is a protein-coding gene located on chromosome 1.
The ALDH9A1 gene encodes the enzyme 4-trimethylaminobutyraldehyde dehydrogenase. This enzyme belongs to the aldehyde dehydrogenase family and is responsible for oxidizing gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). ALDH9A1 exists as a tetramer composed of four identical subunits, each with a molecular weight of 54 kDa.
ALDH9A1 efficiently converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine. It can also oxidize a wide range of aldehydes to their corresponding acids in an NAD-dependent reaction, but with lower efficiency. This enzyme is involved in the oxidation of aldehydes derived from biogenic amines and polyamines.
ALDH9A1 is also known as ALDH4, ALDH7, ALDH9, E3, TMABA-DH, TMABADH, TMABALDH.
Associated Diseases
- Parkinson disease
- multiple sclerosis
- Alzheimer disease
- lysosomal storage disease
- glaucoma
- prostate cancer
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
- hemoglobin D disease
- delta-beta-thalassemia
- dominant beta-thalassemia
- hemoglobin C-beta-thalassemia syndrome
- hemoglobin E-beta-thalassemia syndrome
