AKT1S1
Description
The AKT1S1 (AKT1 substrate 1) is a protein-coding gene located on chromosome 19.
Proline-rich AKT1 substrate 1 (PRAS) is a protein that in humans is encoded by the AKT1S1 gene.
AKT1S1 is a negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), a key nutrient sensor that promotes growth and biosynthesis. In the absence of insulin and nutrients, AKT1S1 binds to mTORC1 and directly inhibits its activity. When insulin and nutrients are present, AKT1S1 detaches from mTORC1. The activity of AKT1S1 is influenced by its phosphorylation state and interaction with 14-3-3 proteins. AKT1S1 may also play a role in nerve growth factor-mediated neuroprotection.
AKT1S1 is also known as Lobe, PRAS40.
Associated Diseases
- nonpapillary renal cell carcinoma
- cancer
- pachyonychia congenita
- autism spectrum disorder - epilepsy - arthrogryposis syndrome
