AKR1B10
Description
The AKR1B10 (aldo-keto reductase family 1 member B10) is a protein-coding gene located on chromosome 7.
AKR1B10, or Aldo-keto reductase family 1 member B10, is an enzyme encoded by the AKR1B10 gene in humans. It belongs to the aldo/keto reductase superfamily, which includes over 40 known enzymes and proteins. AKR1B10 efficiently reduces aliphatic and aromatic aldehydes and is less active on hexoses. It is highly expressed in the adrenal gland, small intestine, and colon, and may be involved in liver carcinogenesis.
AKR1B10 catalyzes the reduction of various carbonyl-containing compounds to their corresponding alcohols using NADPH as a cofactor. It exhibits strong activity towards all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. AKR1B10 plays a crucial role in detoxifying dietary and lipid-derived unsaturated carbonyls, including crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal, and their glutathione-conjugates (GS-carbonyls). However, it does not show reductase activity towards glucose.
AKR1B10 is also known as AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI.
