AKIRIN2
Description
The AKIRIN2 (akirin 2) is a protein-coding gene located on chromosome 6.
Akirin-2 is a protein encoded by the AKIRIN2 gene in humans. The gene's location and details can be found in the UCSC Genome Browser.
Akirin-2 acts as a molecular adapter, linking various multiprotein complexes and influencing several biological processes, including embryonic development, immunity, myogenesis, and brain development. It plays a critical role in nuclear protein degradation by facilitating the import of proteasomes into the nucleus. Akirin-2 directly binds to assembled 20S proteasomes and the nuclear import receptor IPO9, bridging them and mediating the transport of pre-assembled proteasome complexes through the nuclear pore. It contributes to innate immunity by regulating interleukin-6 (IL6) production downstream of Toll-like receptor (TLR), bridging NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to IL6 induction. Furthermore, Akirin-2 is involved in adaptive immunity by promoting B-cell activation. In brain development, it is essential for the survival and proliferation of cerebral cortical progenitor cells. Akirin-2 also plays a crucial role in myogenesis, being required for skeletal muscle formation and development, likely by regulating the expression of muscle differentiation factors. Additionally, it facilitates interdigital tissue regression during limb development.
AKIRIN2 is also known as C6orf166, FBI1, dJ486L4.2.
