AK6
Description
The AK6 (adenylate kinase 6) is a protein-coding gene located on chromosome 5.
AK6 is a broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. It also possesses ATPase activity. AK6 is involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. AK6 associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. AK6 may temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis. AK6 prefers AMP and dAMP as substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. AK6 accepts all nucleoside triphosphates as phosphate donors, including ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. AK6 may be involved in regulation of Cajal body (CB) formation.
AK6 is also known as AD-004, CGI-137, CINAP, CIP, hCINAP.
