AHCTF1
Description
The AHCTF1 (AT-hook containing transcription factor 1) is a protein-coding gene located on chromosome 1.
The AHCTF1 gene in humans encodes the ELYS protein. ELYS is a protein that is involved in the assembly of the nuclear pore complex (NPC), which is a channel that allows molecules to move in and out of the nucleus. ELYS is also involved in the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis, and in the completion of cytokinesis.
ELYS is crucial for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. It is thought to initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Additionally, ELYS is necessary for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the successful completion of cytokinesis.
AHCTF1 is also known as ELYS, MST108, MSTP108, TMBS62.
