AGER
Description
The AGER gene, encoding the receptor for advanced glycation end products (RAGE), plays a crucial role in inflammation and cellular responses to stress. RAGE, a multi-ligand receptor, binds to various ligands, including advanced glycation end products (AGEs), amyloid-beta, and S100 proteins, triggering downstream signaling pathways that contribute to inflammation, oxidative stress, and cellular dysfunction. AGER gene expression is influenced by various factors, including age, diabetes, and environmental stressors. The interplay between AGER gene expression and its ligands has been implicated in the pathogenesis of various diseases, highlighting its significance as a potential therapeutic target.
Associated Diseases
- Alzheimer‘s disease
- Diabetes
- Cardiovascular disease
- Cancer
- Neurodegenerative diseases
- Inflammatory bowel disease
- Chronic kidney disease
- Obesity
Did you know?
AGER gene expression is significantly upregulated in response to stress and inflammation, suggesting a feedback loop where inflammation further amplifies RAGE signaling.
