AGAP3
Definition
Agap3 (Arginylglycylaspartic acid binding protein 3) is a protein that plays a crucial role in the adhesion of cells to the extracellular matrix (ECM). It is a member of the integrin-linked kinase (ILK) family of proteins, which are involved in various cellular processes, including cell migration, proliferation, and differentiation. Agap3 is expressed in many tissues, including the brain, heart, liver, and kidneys.
Structure
The agap3 protein contains four domains:
- An N-terminal domain that binds to integrins.
- A central domain that interacts with the actin cytoskeleton.
- A C-terminal domain that binds to other proteins, including ILK.
Function
Agap3 is involved in the following functions:
- Cell adhesion: Agap3 binds to integrins, which are transmembrane proteins that link the ECM to the actin cytoskeleton. This helps to anchor cells to the ECM and allows them to sense the extracellular environment.
- Cell migration: Agap3 is involved in cell migration by regulating the assembly and disassembly of the actin cytoskeleton.
- Cell proliferation: Agap3 has been shown to promote cell proliferation in some cell types.
- Cell differentiation: Agap3 may play a role in cell differentiation by regulating the expression of certain genes.
Associated Diseases
Mutations in the agap3 gene have been linked to the following diseases:
- Alzheimer‘s disease: Agap3 has been shown to be decreased in the brains of Alzheimer‘s disease patients. This suggests that agap3 may play a role in the development of Alzheimer‘s disease.
- Cancer: Agap3 has been shown to be overexpressed in some cancer cells. This suggests that agap3 may play a role in cancer development and progression.
Did you Know ?
Agap3 is expressed in the highest levels in the brain. This suggests that agap3 may play an important role in brain function.
