ADRM1
Description
The ADRM1 (ADRM1 26S proteasome ubiquitin receptor) is a protein-coding gene located on chromosome 20.
The ADRM1 gene encodes the Proteasomal ubiquitin receptor ADRM1 protein, a subunit of the 19S proteasome complex. This non-ATPase subunit is part of the 19S regulator base, also known as Rpn13 in yeast. The gene has 10 exons and is located on chromosome 20q13.33. The protein is 42 kDa in size, composed of 407 amino acids, and has a calculated theoretical pI of 4.95. ADRM1 is an integral plasma membrane protein that promotes cell adhesion and is thought to undergo O-linked glycosylation. Its expression is induced by gamma interferon in some cancer cells. Two transcript variants encoding the same protein have been identified for this gene. The 26S proteasome complex consists of a 20S core particle (CP) and one or two 19S regulatory particles (RP), which are responsible for distinct structural features and biological functions.
ADRM1 is a component of the 26S proteasome, a multiprotein complex that degrades ubiquitinated proteins using ATP. This process is essential for maintaining protein homeostasis by removing misfolded, damaged, or unnecessary proteins. The proteasome plays a role in various cellular processes, including cell cycle progression, apoptosis, and DNA damage repair. ADRM1 functions as a proteasomal ubiquitin receptor, engaging and activating deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 associates reversibly with the 19S regulatory particle, while PSMD14 is a core subunit of the proteasome lid subcomplex.
ADRM1 is also known as ARM-1, ARM1, GP110, PSMD16.
Associated Diseases
- prostate cancer
- breast cancer
- partial androgen insensitivity syndrome
- cancer
- 46,XX testicular disorder of sex development
- Kallmann syndrome
- 46,XY partial gonadal dysgenesis
- ring chromosome Y
- hypogonadotropic hypogonadism 23 with or without anosmia
