ADIPOR2
Adipor2: A Key Regulator of Metabolism and Adipogenesis
Description
Adipor2 (also known as Adiponectin Receptor 2) is a G protein-coupled receptor (GPCR) that plays a crucial role in regulating metabolism and adipogenesis. It is expressed primarily in skeletal muscle, adipose tissue, and the liver, and binds to the hormone adiponectin, an adipokine secreted by adipose tissue.
Associated Diseases
Dysregulation of adipor2 signaling has been linked to several metabolic disorders, including:
- Type 2 Diabetes: Adiponectin levels are decreased in individuals with type 2 diabetes, and studies have shown that decreased adipor2 expression or signaling impairs glucose uptake and insulin sensitivity.
- Obesity: Adiponectin promotes fat oxidation and reduces lipogenesis, and adipor2 deficiency has been associated with increased adiposity and insulin resistance.
- Cardiovascular Disease: Adiponectin has anti-inflammatory and anti-atherosclerotic effects, and adipor2 signaling has been shown to protect against heart disease.
Did you Know ?
Adiponectin deficiency in mice results in a 40% increase in fat mass and a 50% decrease in insulin sensitivity, highlighting the importance of adipor2 signaling in metabolic health.