ACOT8
ACOT8: A Gene with Complex Roles in Health and Disease
Description
Acyl-CoA thioesterase 8 (ACOT8) is a gene that encodes an enzyme involved in the metabolism of fatty acids. ACOT8 plays a crucial role in regulating lipid homeostasis, inflammation, and energy metabolism. It is mainly expressed in the liver, adipose tissue, and macrophages.
Associated Diseases
Dysregulation of ACOT8 has been linked to several diseases, including:
- Non-Alcoholic Fatty Liver Disease (NAFLD): ACOT8 deficiency impairs fatty acid oxidation and promotes lipid accumulation in the liver, contributing to NAFLD development.
- Cardiovascular Disease: Increased ACOT8 expression has been associated with reduced inflammation and improved heart function, suggesting a protective role against cardiovascular disease.
- Inflammatory Diseases: ACOT8 regulates inflammatory responses by controlling the production of pro-inflammatory cytokines. Its deficiency exacerbates inflammation in conditions such as rheumatoid arthritis and sepsis.
- Cancer: ACOT8 has been implicated in tumor growth and metastasis. Its expression is often altered in various types of cancer, affecting lipid metabolism and promoting proliferation.
Did you Know ?
- ACOT8 deficiency is estimated to affect approximately 1 in 500 individuals worldwide.
