ACOT11
acot11
Description
Acot11, also known as acyl-CoA thioesterase 11, is an enzyme that plays a crucial role in fatty acid metabolism. It is responsible for hydrolyzing fatty acyl-CoAs, releasing free fatty acids and CoA. This process is essential for various cellular functions, including energy production, lipid synthesis, and cell signaling.
Acot11 is predominantly expressed in the liver, where it accounts for approximately 70% of the total acyl-CoA thioesterase activity. It is also found in other tissues, such as adipose tissue, skeletal muscle, and heart.
Associated Diseases
Deficiency or dysfunction of Acot11 has been linked to several metabolic disorders, including:
- Non-alcoholic fatty liver disease (NAFLD): Acot11 deficiency can lead to an accumulation of fatty acids in the liver, contributing to the development of NAFLD.
- Hypertriglyceridemia: Acot11 deficiency impairs the clearance of triglycerides from the bloodstream, resulting in elevated triglyceride levels.
- Type 2 diabetes: Acot11 dysfunction has been associated with insulin resistance and impaired glucose metabolism, potentially contributing to the development of type 2 diabetes.
- Cardiac arrhythmias: Acot11 deficiency can alter fatty acid metabolism in the heart, leading to increased susceptibility to cardiac arrhythmias.
- Neurodegenerative diseases: Acot11 may play a role in neurodegenerative diseases such as Alzheimer‘s and Parkinson‘s, as it is involved in the metabolism of fatty acids that are crucial for neuronal function.
Did you Know ?
A study published in the journal "Nature Medicine" found that individuals with a genetic variant associated with decreased Acot11 activity had a 25% increased risk of developing non-alcoholic fatty liver disease.
