ACMSD
Description
The ACMSD gene encodes for the enzyme acetoacetyl-CoA synthetase, which plays a crucial role in the metabolism of ketone bodies. This enzyme catalyzes the conversion of acetoacetate to acetoacetyl-CoA, an essential intermediate in the biosynthesis of cholesterol, fatty acids, and other vital molecules. ACMSD‘s role in regulating cellular metabolism makes it a key player in various physiological processes, including energy production, lipid metabolism, and inflammation. Dysregulation of ACMSD activity has been implicated in several diseases, highlighting its importance in maintaining cellular homeostasis.
Associated Diseases
- Cancer (e.g., colorectal cancer, breast cancer)
- Neurodegenerative disorders (e.g., Alzheimer‘s disease)
- Metabolic disorders (e.g., type 2 diabetes, obesity)
- Cardiovascular diseases
- Inflammation
Did you know?
ACMSD is highly expressed in the liver, a key organ involved in ketone body metabolism. It is also found in other tissues like the brain, heart, and skeletal muscle.
