ABTB2: A Protein with Diverse Roles in Health and Disease


ABTB2 (ankyrin repeat and BTB/POZ domain containing protein 2) is a protein that plays a crucial role in regulating gene expression, cellular signaling, and immune function. It is composed of ankyrin repeat domains, which facilitate protein-protein interactions, and a BTB/POZ domain, which is involved in transcriptional repression. ABTB2 is highly expressed in immune cells, particularly T cells and macrophages, and is essential for the proper functioning of these cells.

Associated Diseases

ABTB2 dysregulation has been implicated in a range of diseases, including:

  • Autoimmune diseases: ABTB2 deficiency can lead to autoimmune disorders such as systemic lupus erythematosus (SLE) and rheumatoid arthritis.
  • Inflammatory diseases: ABTB2 helps regulate inflammatory responses, and its dysfunction can contribute to chronic inflammatory conditions such as asthma and inflammatory bowel disease.
  • Cancer: ABTB2 has been found to have both tumor-promoting and tumor-suppressing effects, depending on the context.

Did you Know ?

Studies have shown that ABTB2 deficiency in mice results in a dramatic increase in autoimmune disease susceptibility. Mice lacking ABTB2 develop severe SLE-like symptoms, including kidney inflammation, autoantibody production, and increased immune cell activation.

Disclaimer: The information provided here is not exhaustive by any means. Always consult your doctor or other qualified healthcare provider with any questions you may have regarding a medical condition, procedure, or treatment, whether it is a prescription medication, over-the-counter drug, vitamin, supplement, or herbal alternative.