ABHD3
ABHD3: The Enzyme with a Dual Role in Metabolism and Immune Regulation
Description
Abhydrolase domain containing 3 (ABHD3) is an enzyme that belongs to the family of phosphodiesterases. It is involved in the hydrolysis of phospholipids and glycerophospholipids, thereby playing a crucial role in lipid metabolism. ABHD3 is widely expressed in various tissues, including the liver, adipose tissue, and immune cells.
Associated Diseases
Dysregulation of ABHD3 activity has been linked to several diseases, including:
- Obesity: ABHD3 deficiency in mice leads to increased adiposity and insulin resistance.
- Diabetes: ABHD3 is involved in the regulation of glucose and insulin signaling.
- Cardiovascular disease: ABHD3 deficiency impairs lipid metabolism and promotes atherosclerosis.
- Immune disorders: ABHD3 modulates immune responses and is implicated in autoimmune diseases such as rheumatoid arthritis and multiple sclerosis.
Did you Know ?
In individuals with type 2 diabetes, decreased ABHD3 activity has been associated with a 25% increased risk of developing diabetic complications, such as cardiovascular disease and kidney failure.
