ABCC10
Abcc10: A Gene Associated with Multiple Cancers
Description
ATP-binding cassette sub-family C member 10 (ABCC10) is a transmembrane protein that plays a crucial role in cellular detoxification. It belongs to the family of ABC transporters, which are responsible for pumping various substrates across the cell membrane. ABCC10 specifically mediates the efflux of glutathione conjugates, xenobiotics, and certain drugs from cells.
Associated Diseases
Mutations or alterations in the ABCC10 gene have been linked to several types of cancer, including:
- Lung cancer: ABCC10 expression is decreased in lung cancer cells, impairing their ability to detoxify carcinogens, thus promoting tumorigenesis.
- Breast cancer: Dysregulation of ABCC10 expression has been associated with increased risk and poor prognosis of breast cancer.
- Prostate cancer: Alterations in ABCC10 function may contribute to prostate cancer development and drug resistance.
- Hepatocellular carcinoma (HCC): Downregulation of ABCC10 has been observed in HCC, reducing the liver's ability to detoxify harmful substances.
Did you Know ?
According to a study published in the journal "Cancer Research," decreased ABCC10 expression is found in approximately 60% of non-small cell lung cancers, highlighting its potential significance in cancer development.
