AADAT
The AADAT gene encodes a protein called Aminoadipate Aminotransferase (AADAT).
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Function:
- AADAT is a transaminase with broad substrate specificity.
- It has transaminase activity towards several compounds, including aminoadipate, kynurenine, methionine, and glutamate.
- Additionally, it shows activity towards tryptophan, aspartate, and hydroxykynurenine.
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Diseases Associated:
- Hydroxykynureninuria: AADAT is associated with this metabolic disorder.
- Detrusor Sphincter Dyssynergia: Although less well-established, AADAT has been implicated in this condition as well.
