Anti-aminoacyl-tRNA synthetase antibodies (anti-aaRS) are a group of autoantibodies that target various aminoacyl-tRNA synthetases (aaRSs), enzymes responsible for protein synthesis. These antibodies can lead to a spectrum of clinical manifestations, primarily affecting the lungs, skin, and musculoskeletal system.

Associated Diseases

Anti-aaRS antibodies are associated with a range of autoimmune conditions, including:

  • Interstitial lung disease (ILD): Anti-aaRS antibodies can cause chronic inflammation and fibrosis in the lungs, leading to progressive respiratory impairment.
  • Myositis/dermatomyositis: Characterized by muscle weakness, skin rashes, and other systemic symptoms, anti-aaRS antibodies are associated with an increased risk of malignancy.
  • Polymyositis: A chronic inflammatory muscle disease characterized by muscle weakness and pain, which can be associated with anti-aaRS antibodies.
  • Sjögren‘s syndrome: An autoimmune disorder affecting the exocrine glands, anti-aaRS antibodies have been found in some patients with Sjögren‘s syndrome.
  • Other autoimmune diseases: Anti-aaRS antibodies have also been associated with conditions such as rheumatoid arthritis, lupus, and celiac disease.

Did you Know ?

Anti-aaRS antibodies are relatively rare, occurring in approximately 1-2% of patients with ILD. However, they are associated with a high risk of disease progression and poor prognosis.

Disclaimer: The information provided here is not exhaustive by any means. Always consult your doctor or other qualified healthcare provider with any questions you may have regarding a medical condition, procedure, or treatment, whether it is a prescription medication, over-the-counter drug, vitamin, supplement, or herbal alternative.