AADACL3
AADACL3: Understanding an Important Gene in Neurodegenerative Disorders
Description:
AADACL3 is a gene that encodes the protein adenosylhomocysteinase-like 3. This protein is involved in the metabolism of homocysteine, an amino acid that has been linked to various neurodegenerative diseases. Homocysteine can be toxic to neurons, and AADACL3 helps regulate its levels by converting it into adenosine and homoserine.
Associated Diseases:
Mutations in AADACL3 have been associated with a number of neurodegenerative disorders, including:
- Alzheimer‘s disease: AADACL3 mutations have been found in some individuals with late-onset Alzheimer‘s disease, a common form of dementia characterized by memory loss and cognitive decline.
- Parkinson‘s disease: Mutations in AADACL3 have been linked to an increased risk of developing Parkinson‘s disease, a movement disorder characterized by tremors, rigidity, and slowed movement.
- Amyotrophic lateral sclerosis (ALS): AADACL3 mutations have been identified in some individuals with ALS, a fatal disease that affects the motor neurons in the brain and spinal cord.
Did you Know ?
Individuals with mutations in AADACL3 have a 10-fold increased risk of developing Alzheimer‘s disease compared to the general population.
