A2M-AS1: The Emerging Star in Inflammatory and Metabolic Diseases


A2M-AS1 is a non-coding RNA molecule, specifically a long non-coding RNA (lncRNA), that has garnered increasing attention in the field of biomedical research. It is located on chromosome 12 in humans and is known for its role in regulating gene expression. A2M-AS1 interacts with various proteins and molecules, influencing cellular processes and disease development.

Associated Diseases

A2M-AS1 has been implicated in the pathogenesis of several diseases, including:

  • Cardiovascular diseases: A2M-AS1 promotes vascular inflammation and plaque formation, contributing to atherosclerosis and heart attack risk.
  • Metabolic disorders: A2M-AS1 regulates insulin signaling and lipid metabolism, influencing the development of type 2 diabetes and obesity.
  • Autoimmune diseases: A2M-AS1 is involved in the inflammatory response and immune cell activation, contributing to conditions such as lupus and rheumatoid arthritis.

Did you Know ?

Research has shown that individuals with high levels of A2M-AS1 have a significantly increased risk of developing cardiovascular disease. One study found that those with the highest levels of A2M-AS1 had a 3-fold greater risk of heart attack compared to those with the lowest levels.

Disclaimer: The information provided here is not exhaustive by any means. Always consult your doctor or other qualified healthcare provider with any questions you may have regarding a medical condition, procedure, or treatment, whether it is a prescription medication, over-the-counter drug, vitamin, supplement, or herbal alternative.