TRPC3
Description
The TRPC3 (transient receptor potential cation channel subfamily C member 3) is a protein-coding gene located on chromosome 4.
TRPC3 is a protein involved in the regulation of vascular tone, cell growth, proliferation, and pathological hypertrophy. It is a member of the TRPC3/6/7 subfamily of diacylglycerol-sensitive cation channels that regulate intracellular calcium. TRPC3 is important in maintaining a tonic inward depolarizing current that regulates resting membrane potential and promotes regular neuronal firing. Inhibition of TRPC3 leads to cellular hyperpolarization, which can result in slower and more irregular neuronal firing. TRPC3 is preferentially expressed in non-excitable cell types, such as oligodendrocytes, but is also found in basal ganglia output neurons. It plays a role in mGluR-mediated EPSPs and is involved in the regulation of respiratory rhythms.
TRPC3 forms a receptor-activated, non-selective, calcium-permeable cation channel. It can be activated by receptor tyrosine kinases or G-protein coupled receptors through a phosphatidylinositol second messenger system.
TRPC3 is also known as SCA41, TRP3.
