TRIM8
Description
The TRIM8 (tripartite motif containing 8) is a protein-coding gene located on chromosome 10.
TRIM8 is an E3 ubiquitin ligase involved in various biological processes, including cell survival, differentiation, apoptosis, and particularly the innate immune response. It promotes interferon-gamma signaling by degrading the repressor SOCS1 via the proteasome. TRIM8 positively regulates TNFalpha and IL-1beta signaling pathways by inducing Lys-63-linked polyubiquitination of the MAP3K7/TAK1 component, leading to NF-kappa-B activation. It modulates STAT3 activity by negatively regulating PIAS3, either by degrading it through the ubiquitin-proteasome pathway or by excluding it from the nucleus. TRIM8 negatively regulates TLR3/4-mediated innate immune responses by catalyzing Lys-6- and Lys-33-linked polyubiquitination of TICAM1, disrupting the TICAM1-TBK1 interaction.
TRIM8 is also known as FSGSNEDS, GERP, RNF27.
Associated Diseases
- Focal segmental glomerulosclerosis and neurodevelopmental syndrome
- Early infantile epileptic encephalopathy
