SIN3A
Description
The SIN3A (SIN3 transcription regulator family member A) is a protein-coding gene located on chromosome 15.
SIN3A is a protein that in humans is encoded by the SIN3A gene. It is a transcriptional regulatory protein that contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions. These interactions may mediate repression by the Mad-Max complex. SIN3A has been shown to interact with a number of proteins, including those involved in transcription, cell cycle regulation, and neuron differentiation.
SIN3A acts as a transcriptional repressor. It corepresses REST and interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. SIN3A also interacts with MXD1-MAX heterodimers to repress transcription by tethering itself to DNA. It cooperatively represses transcription with OGT in parallel with histone deacetylation. SIN3A is involved in the control of circadian rhythms and is required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. SIN3A cooperates with FOXK1 to regulate cell cycle progression, likely by repressing cell cycle inhibitor gene expression. It is required for cortical neuron differentiation and callosal axon elongation.
SIN3A is also known as CHR15DELq24, DEL15Q24, WITKOS.
Associated Diseases
- Witteveen-Kolk syndrome
- SIN3A-related intellectual disability syndrome due to a point mutation
- 15q24 microdeletion syndrome
