PPP2CA
Description
The PPP2CA (protein phosphatase 2 catalytic subunit alpha) is a protein-coding gene located on chromosome 5.
The PPP2CA gene encodes the catalytic subunit alpha of protein phosphatase 2A (PP2A). PP2A is a major Ser/Thr phosphatase involved in regulating cell growth and division. It consists of a core enzyme composed of a catalytic subunit and a regulatory subunit that can associate with various regulatory subunits.
PP2A-alpha is the major phosphatase for microtubule-associated proteins (MAPs). It can regulate the activity of various kinases, including phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. It cooperates with SGO2 to protect centromeric cohesin during meiosis I. PP2A-alpha can dephosphorylate proteins like SV40 large T antigen and p53/TP53. It activates RAF1 by dephosphorylating it at 'Ser-259'. It also mediates dephosphorylation of WEE1, preventing its degradation and promoting the G2/M checkpoint. PP2A-alpha can dephosphorylate MYC, promoting its degradation, and FOXO3, promoting its stabilization. It catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting NLRP3 inflammasome assembly.
PPP2CA is also known as HJS3, NEDLBA, PP2Ac, PP2CA, PP2Calpha, RP-C.
