PINK1-AS
Pink1-AS Gene: An Unraveling Mystery in Neurological Health
Description
The pink1-antisense gene (pink1-AS), located on chromosome 22, is a non-coding RNA molecule that plays a crucial role in regulating the expression of the pink1 gene. Pink1 protein is a key component of the mitochondria, the energy powerhouses of cells, and is involved in various cellular processes, including mitochondrial quality control, cellular metabolism, and apoptosis.
Associated Diseases
Mutations and dysregulation of the pink1-AS gene have been linked to several neurological disorders, including:
- Parkinson‘s disease: Disruption of the pink1-AS gene has been found in patients with Parkinson‘s disease, a neurodegenerative disorder characterized by progressive motor impairments.
- Alzheimer‘s disease: Studies suggest that alterations in pink1-AS expression may contribute to the development of Alzheimer‘s disease, another neurodegenerative disorder affecting memory and cognition.
- Amyotrophic lateral sclerosis (ALS): Mutations in the pink1-AS gene have been associated with an increased risk of developing ALS, a progressive neuromuscular disease.
Did you Know ?
- Approximately 1 in 500 individuals worldwide carry a mutation in the pink1-AS gene, making it a relatively common genetic variation.
