NAA15
Description
The NAA15 (N-alpha-acetyltransferase 15, NatA auxiliary subunit) is a protein-coding gene located on chromosome 4.
The NAA15 gene encodes a protein known as N-alpha-acetyltransferase 15, NatA auxiliary subunit. It is also called Gastric cancer antigen Ga19, NMDA receptor-regulated protein 1 (NARG1), and Tbdn100. This protein is part of the NatA complex, which adds an acetyl group to the N-terminal amino group of newly synthesized proteins. NAA15 is located on chromosome 4q31.1 and contains 23 exons. There is one known transcript variant. A gene duplication, NAA16, shares 70% sequence identity with NAA15. The NAA15 gene is found on chromosome 2 D in mice and contains 20 exons, while the NAA16 gene is located on chromosome 14 D3 and consists of 21 exons.
The NAA15 protein is an auxiliary subunit of N-terminal acetyltransferase complexes, which display alpha (N-terminal) acetyltransferase (NAT) activity. This activity is important for vascular, hematopoietic and neuronal growth and development. NAA15 is required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), NAA15 up-regulates transcription from the osteocalcin promoter.
NAA15 is also known as Ga19, MRD50, NARG1, NAT1P, NATH, TBDN, TBDN100.
