NAA10
Description
The NAA10 (N-alpha-acetyltransferase 10, NatA catalytic subunit) is a protein-coding gene located on chromosome X.
NAA10 is an N-terminal acetyltransferase that catalyzes the addition of an acetyl group to the N-terminus of proteins. This activity plays a crucial role in a wide range of cellular processes, including protein stability, localization, and interactions with other molecules.
NAA10, also known as N-terminal acetyltransferase 10, is a protein that plays a crucial role in acetylation, a process that modifies proteins and influences their function. It acts as the catalytic subunit of N-terminal acetyltransferase complexes, specifically NatA, NatE, and NatA/HYPK complexes. NAA10 primarily catalyzes the addition of an acetyl group to the amino terminus (N-terminus) of proteins, a process known as N-terminal acetylation. This modification is essential for various cellular processes, including protein stability, localization, and interactions with other molecules. One of NAA10's key functions is to acetylate proteins lacking the initiator methionine, a common amino acid at the beginning of many proteins. It also exhibits internal acetylation activity, particularly towards HIF1A, a protein involved in oxygen sensing and cellular responses to hypoxia. In addition, NAA10 regulates the activity of various proteins, including MYLK, TSC2, and HSPA1A/HSPA1B, through acetylation. For instance, it represses MYLK kinase activity, inhibiting tumor cell migration, and stabilizes TSC2, suppressing mTOR signaling and cancer development. Moreover, NAA10 enhances the chaperone activity of HSPA1A/HSPA1B, promoting their interaction with co-chaperones. It also interacts with and acetylates HIST1H4A, a protein involved in chromatin structure. Overall, NAA10's acetylation activity contributes to a diverse range of cellular processes, including growth and development, protein degradation, cell migration, and cell signaling.
NAA10 is also known as ARD1, ARD1A, ARD1P, DXS707, LZMS, MAA, MCOPS1, NATD, OGDNS, TE2, hARD1.
