LGI1 : leucine rich glioma inactivated 1
Description
The LGI1 (leucine rich glioma inactivated 1) is a protein-coding gene located on chromosome 10.
The LGI1 gene provides instructions for making a protein called leucine-rich glioma inactivated 1 (Lgi1) or epitempin, primarily found in neurons in the brain, including the temporal lobe. This protein likely contributes to normal brain development and might be involved in the function of potassium channels in neurons, which are crucial for normal electrical signaling. Epitempin may also help regulate communication between neurons by binding to a receptor protein called ADAM22 on the surface of neurons, together controlling the release of neurotransmitters. While the precise role of epitempin in the brain remains uncertain, its potential involvement in brain development, potassium channel function, and neuronal communication highlights its significance.
LGI1 is also known as ADLTE, ADPAEF, ADPEAF, EPITEMPIN, EPT, ETL1, IB1099.
