KCNQ5
Description
The KCNQ5 (potassium voltage-gated channel subfamily Q member 5) is a protein-coding gene located on chromosome 6.
KCNQ5 is a human gene encoding a protein that belongs to the KCNQ potassium channel gene family. It's expressed in specific brain regions and skeletal muscle. The encoded protein generates currents that activate slowly with depolarization and can form heteromeric channels with KCNQ3. These currents share features with M-currents, including voltage dependence and inhibitor sensitivity. They are also inhibited by M1 muscarinic receptor activation. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, although only one has been fully characterized. KCNQ5 has been shown to interact with KvLQT3.
KCNQ5 forms a potassium channel with KCNQ3, contributing to M-type current, a slowly activating and deactivating potassium conductance crucial for regulating neuronal excitability. This channel is insensitive to tetraethylammonium but inhibited by barium, linopirdine, and XE991. It is activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1.
KCNQ5 is also known as Kv7.5, MRD46.
