ERBB4

ERBB4: An Essential Receptor Tyrosine Kinase

Description

ERBB4, also known as HER4 or EGFR4, is a receptor tyrosine kinase (RTK) that belongs to the epidermal growth factor receptor (EGFR) family. It is a transmembrane protein composed of an extracellular ligand-binding domain, a transmembrane domain, and an intracellular catalytic domain. ERBB4 plays a pivotal role in various cellular processes, including cell growth, differentiation, survival, and migration.

Associated Diseases

Dysregulation of ERBB4 signaling has been implicated in the development of several diseases, including:

• Cancers: ERBB4 overexpression and mutations have been found in various cancers, such as lung, breast, and colon cancer. Its activation can promote cell proliferation, migration, and angiogenesis, contributing to tumor growth and metastasis.
• Neurological disorders: Aberrant ERBB4 signaling has been linked to neurodevelopmental disorders, such as autism spectrum disorder (ASD), and neurodegenerative diseases, including Alzheimer‘s disease and Parkinson‘s disease. It has been found to affect neuronal development, synaptic plasticity, and cognitive function.
• Cardiovascular diseases: ERBB4 is involved in the regulation of cardiac function. Its dysregulation has been associated with cardiac hypertrophy, heart failure, and myocardial infarction.

Did you Know ?

Approximately 20-30% of non-small cell lung carcinomas (NSCLCs) harbor ERBB4 mutations or amplifications, highlighting its significant role in cancer development.