DGKZ
Description
The DGKZ (diacylglycerol kinase zeta) is a protein-coding gene located on chromosome 11.
Diacylglycerol kinase zeta is an enzyme that in humans is encoded by the DGKZ gene. The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.
== Interactions == DGKZ has been shown to interact with P110α.
DGKZ is a diacylglycerol kinase that converts diacylglycerol (DAG) into phosphatidic acid (PA), regulating the levels of these two bioactive lipids. This function positions DGKZ as a central switch between signaling pathways activated by these second messengers, with different cellular targets and opposing effects in various biological processes. It also plays a role in the biosynthesis of complex lipids. DGKZ lacks acyl chain-dependent substrate specificity among diacylglycerol species but can phosphorylate 1-alkyl-2-acylglycerol in vitro, showing a preference for alkylacylglycerols containing an arachidonoyl group. DGKZ is involved in T cell activation, negatively regulating T-cell receptor signaling, which is partially mediated by diacylglycerol. By generating phosphatidic acid, DGKZ stimulates PIP5KIA activity, regulating actin polymerization. It may also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane.
DGKZ is also known as DAGK5, DAGK6, DGK-ZETA, hDGKzeta.
