CDON

Description

The CDON (cell adhesion associated, oncogene regulated) is a protein-coding gene located on chromosome 11.

CDON is a protein involved in cell-cell interactions and myogenic differentiation. It is a cell surface receptor belonging to the immunoglobulin/fibronectin type III repeat family. It forms complexes with BOC and plays a role in the development of muscle and neural crest cells. CDON binds to hedgehog proteins, including Sonic Hh, Indian Hh, and Desert Hh. Mutations in CDON can affect the sonic hedgehog pathway, which is essential for cell proliferation, differentiation, and tissue development. CDON is thought to be involved in the differentiation of midbrain dopaminergic neurons through its interaction with the Shh signaling pathway.

CDON is part of a cell-surface receptor complex that facilitates communication between muscle precursor cells, contributing to the differentiation of muscle cells.

CDON is also known as CDO, CDON1, HPE11, Ihog, ORCAM.

Associated Diseases

• Midline interhemispheric variant of holoprosencephaly
• Septopreoptic holoprosencephaly
• Microform holoprosencephaly
• Pituitary stalk interruption syndrome
• Holoprosencephaly 11
• Semilobar holoprosencephaly
• Lobar holoprosencephaly
• Alobar holoprosencephaly