CDK13
Description
The CDK13 (cyclin dependent kinase 13) is a protein-coding gene located on chromosome 7.
CDK13 is an enzyme encoded by the CDK13 gene in humans. It belongs to the cyclin-dependent serine/threonine protein kinase family, known for their roles in cell cycle control, differentiation, and apoptosis. CDK13 has unusually large N- and C-termini and is expressed in various tissues. While its exact function is unknown, mutations in CDK13 cause a developmental disorder. Two alternative spliced variants have been identified.
CDK13 is a cyclin-dependent kinase that plays a role in RNA splicing and transcription elongation. It phosphorylates the C-terminal domain (CTD) of RNA polymerase II, a key regulator of transcription elongation. CDK13 also phosphorylates SRSF1/SF2, which is involved in RNA splicing. CDK13 is important for hematopoiesis and interacts with HIV-1 Tat protein during HIV-1 infection, increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.
CDK13 is also known as CDC2L, CDC2L5, CHDFIDD, CHED, hCDK13.
