CCDC78
Description
The CCDC78 (coiled-coil domain containing 78) is a protein-coding gene located on chromosome 16.
CCDC78, also known as C16orf25, FLJ34512, CNM4, and JFP10, is a protein encoded by the CCDC78 gene located on chromosome 16. The gene spans 10,892 base pairs and encodes a protein of 438 amino acids with a molecular weight of approximately 4.852 kDa. CCDC78 is ubiquitously expressed at moderate levels and has several isoforms, including one associated with a unique congenital myopathy. While no paralogs exist, several orthologs have been identified. The precise function of CCDC78 remains unknown, but evidence suggests its involvement in skeletal muscle contraction.
CCDC78 is a component of the deuterosome, a structure that promotes the formation of new centrioles in multiciliated cells, which can produce over 100 centrioles. This process, known as deuterosome-mediated centriole amplification, takes place in fully differentiated multiciliated cells during the G1/0 phase of the cell cycle, not during the S phase. CCDC78 is crucial for this centriole amplification and is required for the proper localization of the protein CEP152 to the deuterosome.
CCDC78 is also known as C16orf25, CNM4, JFP10, hsCCDC78.
