UNC80 : unc-80 homolog, NALCN channel complex subunit

Description

UNC80, also known as Synaptotagmin-like protein 1 (SYTL1), is a gene that encodes a protein crucial for regulating synaptic vesicle exocytosis, a fundamental process for neuronal communication. The UNC80 protein is localized to the presynaptic terminal of neurons and plays a role in calcium-dependent exocytosis, ensuring the release of neurotransmitters into the synaptic cleft. Its function is critical for maintaining normal neuronal activity, learning, and memory. Mutations in the UNC80 gene can lead to various neurological disorders, highlighting its importance in brain function.

Associated Diseases

• Intellectual Disability
• Epilepsy
• Autism Spectrum Disorder
• Schizophrenia
• Neurodevelopmental Disorders

Did you know?

UNC80 shares a significant homology with the Synaptotagmin family, suggesting a shared evolutionary origin and potentially similar functional roles in different organisms.