TRIM32

Description

TRIM32, short for Tripartite Motif Containing 32, is a gene that encodes a protein crucial for maintaining muscle integrity and function. This protein acts as a ubiquitin ligase, a molecular tagger that marks proteins for degradation. TRIM32 plays a vital role in regulating the turnover of muscle proteins, ensuring proper muscle fiber development and repair. It also participates in the removal of damaged or misfolded proteins, preventing their accumulation and potential harm. Dysregulation of TRIM32 expression or function can lead to a range of muscular disorders, highlighting its critical role in muscle homeostasis.

Associated Diseases

• Limb-girdle muscular dystrophy type 2H (LGMD2H)
• Myopathy with early-onset cataracts (MEOC)
• Scapuloperoneal muscular dystrophy (SPMD)
• Distal myopathy
• Myofibrillar myopathy
• Inclusion body myositis (IBM)
• Amyotrophic lateral sclerosis (ALS)

Did you know?

TRIM32 is a highly conserved gene, meaning it has changed very little over millions of years of evolution, reflecting its critical importance for muscle function.